Association of Platelet Indices with Severity and Prognosis of Acute Ischemic Stroke

Authors

  • Issa Layka Tishreen University
  • Susan Shemali Tishreen University
  • Sulaiman Nukari Tishreen University

Abstract

Introduction: Platelet indices reflect the function and activity of platelets. Results from most international studies about the association of platelet indices and acute ischemic stroke are still conflicting. Our goal in this study was to identify an association between platelet indices and the severity and prognosis of acute ischemic stroke.

Methods: We studied 156 patients with acute ischemic stroke who were admitted to the neurology unit in Tishreen University Hospital during the period from August 2019 to July 2020, and compared them with 113 control subjects. The severity of ischemic stroke was evaluated according to NIHSS, and patients were stratified in prognostic groups based on mRS. Platelet indices in patients were determined 48 hours or less after the onset of symptoms.

Results: There was a negative correlation between platelet count and acute ischemic stroke (246.7±77.9×109\L in patients vs. 267.9±84.6×109\L in controls, p-value=0.03). There was a statistically significant association between higher Mean Platelet Volume (MPV) values and acute ischemic stroke (11.3±2.8 fL in patients vs. 8.9±2.8 fL in controls,
p-value=0.02). There was also an association between MPV and the severity of ischemic stroke (11.1±1.4 fL in severe ischemic strokes, p-value=0.03). MPV was also related to the prognosis of acute ischemic stroke (11.2±1.1 fL in bad prognosis group according to mRS, p-value=0.03).

Author Biographies

Issa Layka, Tishreen University

Professor - Department of Internal Medicine – Faculty of Medicine

Susan Shemali, Tishreen University

Assistant Professor – Department of Laboratory Medicine – Faculty of Medicine

Sulaiman Nukari, Tishreen University

Postgraduate Student (Master) – Department of Internal Medicine – Faculty of Medicine

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Published

2020-11-13

How to Cite

1.
لايقة ع, الشمالي س, النقري س. Association of Platelet Indices with Severity and Prognosis of Acute Ischemic Stroke. Tuj-hlth [Internet]. 2020Nov.13 [cited 2024Nov.24];42(5). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10087

Issue

Vol. 42 No. 5 (2020): Tishreen University Journal for Research and Scientific Studies - Medical Sciences Series

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Articles

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