A comparison between intralesional sodium chloride 12% solution and sodium meglumine solution in the treatment of cutaneous leishmaniasis

Authors

  • Jamal Khaddam Tishreen University
  • Rahaf Shaheen Tishreen University

Abstract

Leishmania disease is a disease caused by several types of protozoan parasites inside the cell belonging to the genus Leishmania, which are transmitted to humans through the bite of a female sand fly.It is considered an endemic disease in Syria and causes an important health problem due to the defective scars it leaves in the absence of treatment.

This study was conducted to compare the efficacy of treating cutaneous leishmaniasis with intralesional injection of 12% aqua sodium chloride solution with intralesional injection of sodium meglumine solution.

The study included 63 patients, whose ages ranged from one year to seventy-one years. The number of males was 40 patients and the number of females was 23 patients.

We found that treatment with sodium meglumine solution gave an excellent response of 70.9% after 6 weeks, while treatment with hypertonic sodium chloride solution 12% led to an excellent response of 50% after 6 weeks. Pain was the most common side effect and was more severe when treatment with hypertonic sodium chloride solution 12%.

Our study showed that hypertonic sodium chloride solution 12% is a safe treatment with no systemic side effects, and it can be considered an inexpensive alternative to sodium meglumine solution by  intralesional injection.

 

Author Biographies

Jamal Khaddam , Tishreen University

Associate  Professor, Department of  Dermatology, Faculty of Medicine

Rahaf Shaheen , Tishreen University

Postgradute Student , Department of  Dermatology, Faculty of Medicine

Downloads

Published

2021-09-16

How to Cite

1.
خدام ج, شاهين ر. A comparison between intralesional sodium chloride 12% solution and sodium meglumine solution in the treatment of cutaneous leishmaniasis. Tuj-hlth [Internet]. 2021Sep.16 [cited 2024Nov.24];43(4). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10889

Issue

Vol. 43 No. 4 (2021): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.