"Preparation of fast disintegrating tablets of Ondansetron Hydrochloride "

Authors

  • Makbola Istanboli Tishreen University
  • Tamim Hammad Tishreen University
  • Wassim Abdelwahed University Aleppo

Abstract

This research aims to prepare Ondansetron Hydrochloride orally disintegrating tablets. Direct compression and lyophilization methods were used in the preparation.

 For the direct  compression method, glucose was used as diluent with different disintigrants such as: Kollidon CL, Ac-di-sol at different concentrations. As for the lyophilization method, different binding agents were used such as: gelatin and PVP K30 with different concentrations of mannitol as building agents.

Tablets (F9) containing 20 mg Kollidon CL with 20 mg Ac-di-sol showed the lowest disintegration time of 30 seconds compared to the other formulations prepared by direct  compression method, while the  lyophilizate FDTs  (L6)  containing 60% mannitol and both gelatin and PVP K30 as a binder was the best formulation prepared by lyophilization method, it had a good external appearance and disintegrated within 12 seconds.

Oral lyophilized FDTs  showed a faster rate of drug release compared to the direct compression FDTs, releasing 77% of ondansetron hydrochloride within the first two minutes, compared to 43% for the direct compressed FDTs (f1 >15 , f2 < 50).

 

Downloads

Published

2023-09-18

How to Cite

1.
استانبولي م, تميم حماد, وسيم عبد الواحد. &quot;Preparation of fast disintegrating tablets of Ondansetron Hydrochloride &quot;. Tuj-hlth [Internet]. 2023Sep.18 [cited 2024Nov.24];45(4):433-49. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/15539

Issue

Vol. 45 No. 4 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.