The Effectiveness of Intravitreal Bevacizumab with or without Triamcinolone Acetonide for Diabetic Macular Edema Treatment
Abstract
Purpose To study effectiveness of Intravitreal Bevacizumab 2.5mg IVB alone or Bevacizumab 1.25mg in combination with 2 mg Triamcinolone Acetonide IVTA in center-involved diabetic macular edema.
Patients and methods: 61 eyes enrolled in this prospective, non-randomized, comparative study ( 36 eyes were injected with IVB, 25 eyes were injected with IVTA + IVB). Evaluation of best-corrected visual acuity BCVA, central macular thickness CMT, and intraocular pressure IOP was conducted at 4,8,12 weeks after treatment.
Results: Significant CMT reduction was observed in each group along the follow-up period (P<0.001). The mean reduction of CMT was more significant in combination IVTA + IVB at 4 weeks (P<0.05). Significant BCVA improvement was observed each group along the follow-up period (P<0.001). BCVA changes between two groups were not significant different at follow-up period (P>0.05). The number of injections was significantly lower in IVTA + IVB group than IVB group (P=0.0045). One patient developed IOP raised more than 21 mmHg, which were treated with anti glaucoma medications.
Conclusion: Bevacizumab 2.5mg Intravitreal injection alone or Bevacizumab 1.25mg in combination with 2 mg Triamcinolone Acetonide had significantly reduced CMT, and this effect was more significant in combination term at short term. Although treatment in both terms had significantly improved BCVA at all follow-up period with no differentiation between the two groups. The combination therapy may reduce the number of injections. Intravitreal injections were not accompanied with significant IOP increas.
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