Liver function disorders in COVID-19 patients admitted to Tishreen University Hospital in Lattakia

Authors

  • yazan aliwa Tishreen University
  • Ismael Hammad Tishreen University
  • Youssef Zreik Tishreen University

Abstract

Purpose : We aim to study the effect of liver function disorders (Alanine aminotransferase ALT / Aspartate aminotransferase AST / Total Bilirubin T.Bili / Direct (Conjugated) Bilirubin D.Bili) on prognosis in COVID-19 patients , with evaluation of a statistically significant relationship between infection with COVID-19 and liver function disorders in terms of gender , age , average hospitalization period , need for mechanical ventilation (ventilator / intensive care unit ICU) and mortality.

Methods :A retrospective cohort study was performed that included 471 COVID-19 patients admitted to the isolation department at Tishreen University Hospital in Lattakia in the period between 2020 – 2021 . We did a retrospective study of the files of patients who met the admission criteria , and studied the aforementioned variables and liver function disorders (ALT / AST / AST/ALT Ratio / T.Bili / D.Bili).

Results :Our study included 471 COVID-19 patients , their average age was 63.21 years , and the percentage of males was (61.36%) (Sex Ratio M;F 1.59:1). The patients were divided according to liver function tests conducted upon admission into two groups , the group of patients who had normal liver function tests (n = 190 , 40.34%) and the group of patients who had abnormal liver function tests (n = 281 , 59,66%).

When comparing the results between the two study groups , we found no statistically significant difference in terms of age (P-value = 0.176) , sex (P-value = 0.165515) , and the average hospitalization period   (P-value = 0.063425) , between the two study arms.

The total death rate reached 251 deaths ( 53.29%) , and this rate was higher in the group of patients with impaired liver functions (60.49%) compared to (42.63%) in the group of patients with normal liver functions , and this constituted a statistically significant difference

 (P-value = 0.000092) . Also the rate of need for mechanical ventilation (ventilator / intensive care unit) was higher in the group of patients  with abnormal liver functions (33.45%) compared to (13.16%) in the group of patients  with normal liver functions , with a statistically significant difference (P-value = 0.000057).

Conclusion : Our study showed that hepatic injury in COVID-19 had a significant effect on survival ,  the need for mechanical ventilation (ventilator / intensive care unit) compared to the absence of this injury  , but it did not significantly affect the average hospitalization period in patients with COVID-19.

We need more studies and  research to characterize causes and the extent of liver damage in COVID-19 , in addition to the effect of SARS-CoV-2 infection on chronic liver diseases.

Downloads

Published

2023-05-18

How to Cite

1.
الليوا ي, اسماعيل حمَاد, يوسف زريق. Liver function disorders in COVID-19 patients admitted to Tishreen University Hospital in Lattakia. Tuj-hlth [Internet]. 2023May18 [cited 2024Apr.28];45(2):413-29. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/14439

Issue

Vol. 45 No. 2 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.