Liver function disorders in COVID-19 patients admitted to Tishreen University Hospital in Lattakia

Authors

  • yazan aliwa Tishreen University
  • Ismael Hammad Tishreen University
  • Youssef Zreik Tishreen University

Abstract

Purpose : We aim to study the effect of liver function disorders (Alanine aminotransferase ALT / Aspartate aminotransferase AST / Total Bilirubin T.Bili / Direct (Conjugated) Bilirubin D.Bili) on prognosis in COVID-19 patients , with evaluation of a statistically significant relationship between infection with COVID-19 and liver function disorders in terms of gender , age , average hospitalization period , need for mechanical ventilation (ventilator / intensive care unit ICU) and mortality.

Methods :A retrospective cohort study was performed that included 471 COVID-19 patients admitted to the isolation department at Tishreen University Hospital in Lattakia in the period between 2020 – 2021 . We did a retrospective study of the files of patients who met the admission criteria , and studied the aforementioned variables and liver function disorders (ALT / AST / AST/ALT Ratio / T.Bili / D.Bili).

Results :Our study included 471 COVID-19 patients , their average age was 63.21 years , and the percentage of males was (61.36%) (Sex Ratio M;F 1.59:1). The patients were divided according to liver function tests conducted upon admission into two groups , the group of patients who had normal liver function tests (n = 190 , 40.34%) and the group of patients who had abnormal liver function tests (n = 281 , 59,66%).

When comparing the results between the two study groups , we found no statistically significant difference in terms of age (P-value = 0.176) , sex (P-value = 0.165515) , and the average hospitalization period   (P-value = 0.063425) , between the two study arms.

The total death rate reached 251 deaths ( 53.29%) , and this rate was higher in the group of patients with impaired liver functions (60.49%) compared to (42.63%) in the group of patients with normal liver functions , and this constituted a statistically significant difference

 (P-value = 0.000092) . Also the rate of need for mechanical ventilation (ventilator / intensive care unit) was higher in the group of patients  with abnormal liver functions (33.45%) compared to (13.16%) in the group of patients  with normal liver functions , with a statistically significant difference (P-value = 0.000057).

Conclusion : Our study showed that hepatic injury in COVID-19 had a significant effect on survival ,  the need for mechanical ventilation (ventilator / intensive care unit) compared to the absence of this injury  , but it did not significantly affect the average hospitalization period in patients with COVID-19.

We need more studies and  research to characterize causes and the extent of liver damage in COVID-19 , in addition to the effect of SARS-CoV-2 infection on chronic liver diseases.

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Published

2023-05-18

How to Cite

1.
الليوا ي, اسماعيل حمَاد, يوسف زريق. Liver function disorders in COVID-19 patients admitted to Tishreen University Hospital in Lattakia. Tuj-hlth [Internet]. 2023May18 [cited 2024Nov.24];45(2):413-29. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/14439

Issue

Vol. 45 No. 2 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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