Determination of sodium methylparaben levels in some locally marketed parenteral pharmaceutical products

Authors

  • Nour Sharaf Tishreen University
  • Faten Alchab Tishreen University

Abstract

This study aims to investigate the presence of sodium methylparaben and determine its concentration in some locally marketed pharmaceutical forms. Therefore, we studied 8  ampoules and two oral syrup locally manufactured samples marketed in the Syrian market,  packaging and labelling test applied to all samples. The studied samples belonged to sex pharmaceutical companies. The concentration of sodium methylparaben was determined by high-performance liquid chromatography (HPLC) using a column (BDS Hypersil C18 250 mm* 4.6 mm) ,  mobile phase: methanol as the organic solution with an acetate buffer in the ratio of 82:18, flow rate: 1 ml/minute, UV detection: 254nm. Packaging test revealed that all of the locally manufactured samples matching to WHO guidelines, The results of HPLC analyse showed  presence of sodium methylparaben in all studied samples, and all samples were within the allowable limit (0.25% for ampoules, 0.2% for oral syrups) according to the Food and Drug Administration (FDA). The specific concentrations ranged between (1.7-2.28 mg/ml for ampoules and 1.2-1.5 mg/ml for medicinal syrups), depending on the HPLC device.

Downloads

Published

2023-12-03

How to Cite

1.
شرف ن, فاتن الشب. Determination of sodium methylparaben levels in some locally marketed parenteral pharmaceutical products. Tuj-hlth [Internet]. 2023Dec.3 [cited 2024Nov.28];45(5):357-6. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/16177

Issue

Vol. 45 No. 5 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.