دراسة مستوى التستوستيرون االمصلي بعد تطبيق المعالجة المثبطة للأندروجين :ADH عند مرضى سرطان الموثة النقائلي (خبرة مشفى تشرين الجامعي في اللاذقية بين عامي 2013-2014)

Authors

  • سامر عاقل
  • ميخائيل جرجس
  • تغريد مرهج

Abstract

شملت هذه الدراسة 30 مريضا لديهم سرطان موثة نقائلي , راجعوا قسم الأورام في مشفى تشرين الجامعي في اللاذقية بين عامي 2014 -2013جميع المرضى درسوا من حيث الscore gleason(مشعر غليسون) والعمر ومشعر كتلة الجسم ((BMI. جميع المرضى تلقوا علاج بشادات LHRH(goserelin 3,6 mg) بحقن شهرية تحت الجلد مع مشاركته خلال أول أسبوعين بمثبطات الأندروجين المحيطية. تم عيار ال PSA وال Testosteron قبل بدء العلاج ثم بعد شهر واحد ثم بعد 6 أشهر من بدء العلاج ,إضافة إلى مراقبة الاّثار الجانبية للعلاج الهرموني المستخدم والنتائج بعد شهر من العلاج: عدم وجود علاقة بين مشعر كتلة الجسم والتستوستيرون. شادات LHRH تحقق نسبة استجابة تقدر ب 90 %بتخفيضها لللتستوستيرون لقيمأاقل من 50 نغ/دل و76% وصل لديهم التستوستيرون لقيم أقل من 20 نغ /دل.أهم الاّثار الجانبية : الاكتئاب 72% و الهبات الساخنة 33% والصداع 30%. In this study : 30 patients with metastatic prostate cancer who admitted to the department of Oncology, Tishreen University Hospital, Lattakia, Syria between 2013 and 2014 were grouped according to gleason score , age and body mass index. All patient received treatment with LHRH agonist (goserelin 3,6 mg subcutaneous injection monthly) combined with anti-androgen for two weeks. PSA and testosterone were measured in all patients before treatment then after 1 and after 6 month and the side effects were documented. Results post ADH treatment: There is no relationship between body mass index and testosterone level. Hormonal treatment with LHRH agonist reduced testosterone to 50 ng/dl in 90% of the patients, whereas 76%of the cases achieved testosterone levels 20ng/dl. The most common treatment-related adverse event was depression 72% , hot flash 33% and headache 30%.

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Published

2016-07-11

How to Cite

1.
عاقل س, جرجس م, مرهج ت. دراسة مستوى التستوستيرون االمصلي بعد تطبيق المعالجة المثبطة للأندروجين :ADH عند مرضى سرطان الموثة النقائلي (خبرة مشفى تشرين الجامعي في اللاذقية بين عامي 2013-2014). Tuj-hlth [Internet]. 2016Jul.11 [cited 2024Nov.24];37(1). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/1626

Issue

Vol. 37 No. 1 (2015): العلوم الصحية

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