Evaluating RBC indices in the differential diagnosis between iron deficiency anemia and beta-thalassemia trait

Authors

  • Susan Alshmali Tishreen University
  • Firas Hussein Tishreen University
  • Reem Omran Tishreen University

Abstract

Background: Anemia affects more than third of world's population and microcytic hypochromic anemia constitute an important part of anemia

Iron deficiency anemia IDA and beta thalassemia trait BTT are the most common causes of microcytic hypochromic anemia particulary in Syria

To confirm diagnosis we depend on iron studies (iron-TIBC-transferrin receptors) for IDA and hemoglobin analysis for BTT

Purpose: to evaluate the role of RBC indices and formulas in the differential diagnosis between iron deficiency anemia (IDA) and beta-thalassemia trait (BTT) by comparing them with the gold standards of diagnosis.

Methods: This study included 110 outpatients and with hypochromic microcytic anemia according to their complete blood count, all of them underwent the following blood tests: CRP-Ferritin- Hb A2 measurement by hemoglobin electrophoresis\HPLC, and then distributed into 2  groups: 50 patients with iron deficiency anemia, 50 patients with beta thalassemia trait. Ten patients were found to have both IDA and BTT. The study took place in the central laboratory at Tishreen University Hospital in Latakia, between June 2020 and February 2021.

Results: Jayabose was the best discriminant index according to Youden index that is based on sensitivity and specificity (sensitivity+specificity-100)

England and Fraser and Srivastava was the best index for diagnosis of IDA and Ricerca was the best index for diagnosis of BTT

The best cut-off of jayabose was found to be at the point 224 by using Receiver Operation Characteristic (ROC Curve)

Conclusion: according to Youden index, the most important index to discriminate between iron deficiency anemia and beta thalassemia trait was jayabose, and its cut-off is at the point 224

Author Biographies

Susan Alshmali, Tishreen University

Assistant Professor - Faculty of Human Medicine

Firas Hussein, Tishreen University

Associate Professor - Faculty of Human Medicine

Reem Omran, Tishreen University

Postgraduate Student - Faculty of Human Medicine

Downloads

Published

2021-07-06

How to Cite

1.
الشمالي س, حسين ف, عمران ر. Evaluating RBC indices in the differential diagnosis between iron deficiency anemia and beta-thalassemia trait. Tuj-hlth [Internet]. 2021Jul.6 [cited 2024Nov.24];43(3). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10719

Issue

Vol. 43 No. 3 (2021): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)

1 2 > >>