Evaluating RBC indices in the differential diagnosis between iron deficiency anemia and beta-thalassemia trait

Authors

  • Susan Alshmali Tishreen University
  • Firas Hussein Tishreen University
  • Reem Omran Tishreen University

Abstract

Background: Anemia affects more than third of world's population and microcytic hypochromic anemia constitute an important part of anemia

Iron deficiency anemia IDA and beta thalassemia trait BTT are the most common causes of microcytic hypochromic anemia particulary in Syria

To confirm diagnosis we depend on iron studies (iron-TIBC-transferrin receptors) for IDA and hemoglobin analysis for BTT

Purpose: to evaluate the role of RBC indices and formulas in the differential diagnosis between iron deficiency anemia (IDA) and beta-thalassemia trait (BTT) by comparing them with the gold standards of diagnosis.

Methods: This study included 110 outpatients and with hypochromic microcytic anemia according to their complete blood count, all of them underwent the following blood tests: CRP-Ferritin- Hb A2 measurement by hemoglobin electrophoresis\HPLC, and then distributed into 2  groups: 50 patients with iron deficiency anemia, 50 patients with beta thalassemia trait. Ten patients were found to have both IDA and BTT. The study took place in the central laboratory at Tishreen University Hospital in Latakia, between June 2020 and February 2021.

Results: Jayabose was the best discriminant index according to Youden index that is based on sensitivity and specificity (sensitivity+specificity-100)

England and Fraser and Srivastava was the best index for diagnosis of IDA and Ricerca was the best index for diagnosis of BTT

The best cut-off of jayabose was found to be at the point 224 by using Receiver Operation Characteristic (ROC Curve)

Conclusion: according to Youden index, the most important index to discriminate between iron deficiency anemia and beta thalassemia trait was jayabose, and its cut-off is at the point 224

Author Biographies

Susan Alshmali, Tishreen University

Assistant Professor - Faculty of Human Medicine

Firas Hussein, Tishreen University

Associate Professor - Faculty of Human Medicine

Reem Omran, Tishreen University

Postgraduate Student - Faculty of Human Medicine

Published

2021-07-06

How to Cite

1.
الشمالي س, حسين ف, عمران ر. Evaluating RBC indices in the differential diagnosis between iron deficiency anemia and beta-thalassemia trait. Tuj-hlth [Internet]. 2021Jul.6 [cited 2024Jul.16];43(3). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10719

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