The Prognostic Value Of serum D-dimer In Acute Ischemic Stroke Patients
Abstract
Object: Acute ischemic stroke is considered one of the major causes of death and long-term functional disability, and due to the lack of easy and rapid prognostic factors, this study aims to evaluate the predictive role of serum D-dimer upon admission.
Methods: This prospective cohort study included (n=191) patients with acute ischemic stroke who were admitted to Tishreen University Hospital in Lattakia within 48 hours from the onset of symptoms. Serum D-dimer levels were measured upon admission, stroke severity was determined by (NIHSS), and functional outcomes were assessed on the modified Rankin scale (mRs) after 30 days.
Results: Elevated serum D-dimer levels on admission in patients with ischemic stroke is an independent risk factor for predicting the severity of stroke, as higher levels of serum D-dimer were associated with higher severity (OR = 1.5, 95% CI = 1.1–2.4). Also, high serum D-dimer levels on admission were an independent risk factor for predicting poor prognosis mRs ≥3(OR = 19.3, 95% CI = 5.9–62.7), and the highest sensitivity and specificity standard cut-off point for D-dimer is 0.79 mcg/L with a sensitivity of 92.6% and a 88% specificity. The mortality rate among the patients was about 8.4% with a total number of 16 patients after a 30 days follow-up. Patients who died recorded higher values of serum D-dimer with statistical significance (P value <0.001).
Conclusion: Serum D-dimer levels are a promising prognostic biomarker for acute ischemic stroke, as higher levels of serum D-dimer levels on admission were associated with increased stroke severity, poor functional outcome by day 30, and higher mortality by day 30.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.