The Prognostic Value Of serum D-dimer In Acute Ischemic Stroke Patients

Authors

  • abdulhamed ismaiel Tishreen University
  • Eisa Layka Tishreen University
  • Faisal Redwan Tishreen University

Abstract

Object: Acute ischemic stroke is considered one of the major causes of death and long-term functional disability, and due to the lack of easy and rapid prognostic factors, this study aims to evaluate the predictive role of serum D-dimer upon admission.

Methods: This prospective cohort study included (n=191) patients with acute ischemic stroke who were admitted to Tishreen University Hospital in Lattakia within 48 hours from the onset of symptoms. Serum D-dimer levels were measured upon admission, stroke severity was determined by (NIHSS), and functional outcomes were assessed on the modified Rankin scale (mRs) after 30 days.

Results: Elevated serum D-dimer levels on admission in patients with ischemic stroke is an independent risk factor for predicting the severity of stroke, as higher levels of serum D-dimer were associated with higher severity (OR = 1.5, 95% CI = 1.1–2.4). Also, high serum D-dimer levels on admission were an independent risk factor for predicting poor prognosis mRs ≥3(OR = 19.3, 95% CI = 5.9–62.7), and the highest sensitivity and specificity standard cut-off point for D-dimer is 0.79 mcg/L with a sensitivity of 92.6% and a 88% specificity. The mortality rate among the patients was about 8.4% with a total number of 16 patients after a 30 days follow-up. Patients who died recorded higher values ​​of serum D-dimer with statistical significance (P value <0.001).

Conclusion: Serum D-dimer levels are a promising prognostic biomarker for acute ischemic stroke, as higher levels of serum D-dimer levels on admission were associated with increased stroke severity, poor functional outcome by day 30, and higher mortality by day 30.

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Published

2023-03-27

How to Cite

1.
اسماعيل عا, عيسى لايقة, فيصل رضوان. The Prognostic Value Of serum D-dimer In Acute Ischemic Stroke Patients . Tuj-hlth [Internet]. 2023Mar.27 [cited 2024Apr.28];45(1):319-55. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/14069

Issue

Vol. 45 No. 1 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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