A clinical study of the relationship between Triglyceride/Glucose index (TyG index) and Glycated hemoglobin(HbA1c )in patients with Diabetes Mellitus Type 2

Authors

  • Hadeel Nasser Tishreen University
  • Arige Boubou Tishreen University
  • Faisal Radwan Tishreen University

Abstract

Introduction: Diabetes Mellitus is a global health issue due to the huge number of patients worldwide and its devastating complications. ADA recommended achieving a good glycemic control to avoid that by reaching HbA1c ˂ 7%. Insulin resistance is one of the pathophysiology of T2DM many ways have been used to evaluate it including HOMA-IR & HEC and lately TYG index.

Materials and Methods: a total of 83 patients  T2DM were included in this prospective cross sectional  study and divided into 3 groups according to their HbA1c, a group with good control diabetes HbA1c˂7%, a group of intermediate control HbA1c 7-9% ,a group of bad control HbA1c˃ 9%. Anthropometric and biochemical parameters were measured, TYG index was calculated using formula TYG index = ln [fasting glucose(mg/dl) ͯ fasting triglyceride(mg/dl)] / 2

Results: fasting blood glucose and fasting triglyceride and HDL were higher in patients with HbA1c˃7%, TYG index correlates with HbA1c also TYG-BMI & TYG-WC, the receiver area under curve analyze ROC showed TYG index had a maximum area under curve of 0.852 with a cut-off value 4.9 for identifying glycemic control in T2DM sensitivity 85.5% and specificity 63.2%.

Conclusion: TYG index is a useful tool for assessing glycemic control in T2DM and positively correlate with HbA1c, it can be used as a simple, available, and inexpensive alternative to asses glycemic control in T2DM.

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Published

2024-11-10

How to Cite

1.
ناصر ه, أريج بوبو, فيصل رضوان. A clinical study of the relationship between Triglyceride/Glucose index (TyG index) and Glycated hemoglobin(HbA1c )in patients with Diabetes Mellitus Type 2. Tuj-hlth [Internet]. 2024Nov.10 [cited 2024Nov.24];46(4):293-309. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/17721

Issue

Vol. 46 No. 4 (2024): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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