Investigation of Thyroid Disorders in Recently Diagnosed Patients with Breast Cancer in Tishreen University Hospital
Abstract
Introduction: Breast cancer (BC) is one of the most prevalent malignancies worldwide and also Syria. The relationship between thyroid disorders and breast cancer (BC) is debated. Many reports show interesting findings about the nature and the incidence of thyroid disorders in relation to breast cancer.
Objective: The aim of this study was to analyze the prevalence of thyroid disorders in recently diagnosed patients with a positive biopsy for breast cancer prior to specific antitumor treatment, in Tishreen University Hospital.
Materials and Methods: To clarify this controversial issue, a cross-sectional study on thyroid function in recently diagnosed BC patients was performed. Serum thyroid hormones (TSH, FT3, FT4) and thyroperoxidase antibodies (Anti-TPO Abs) levels were evaluated in 50 BC patients before or after surgery, and 30 healthy control women.
Results: Invasive ductal carcinoma is the common histologic subtype of BC 86%. The incidences of thyroid diseases were higher in BC patients than in control individuals, especially subclinical and overt hypothyroidism (64% versus 20%, P=0.002). The mean values for TSH and Anti-TPO abs were significantly higher in BC (P=0.0001) and increasing positively with tumor Grade.
Conclusion: Our results indicate an increased prevalence of subclinical and overt hypothyroidism, higher TSH and A-TPO levels in BC. Our study suggests the existence of an association between hypothyroidism, high TSH and A-TPO levels and BC. However, further studies are required to confirm this association.
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