Synthesis of New Fluorine Derivatives via Mannich Reaction

Authors

  • Farouk Kandil
  • Shahid Moustapha
  • Thawra Ahmad

Abstract

Three New compounds N,N(substituted) amino,N(3(2-fluorenyl))propanone-3.(Ia),(Ib),(Ic), have been prepared using Mannich reaction from 2- Acetyl fluorine with formaldehyde and secondary amine. For(diethanol amine, diethyl Amine, N- methyl. N- phenyl amine) in an acidic medium HCl which gave these compounds:

)N, N bis (2- hydroxy ethyl) amino, N (3 (2-fluorenyl)) propanone-3 (Ia).

)N, N bis (ethyl) amino, N (3 (2- fluorenyl)) prpanone-3 (Ib).

N-methyl. N-phenyl amino, N (3 (2- fluorenyl)) propanone-3 (Ic).

The structure of these compounds have been checked by spectrum analysis: (IR, 1H-NMR,13c-NMR, LC-MS).

تم تصنيع بعض المركبات الجديدةN,Nبيس (مستبدل) أمينو، N (3 (2 - فلورينيل)) بروبانون – 3 (Ic,Ib,Ia)  . عبر تفاعل مانيش بدءاً من 2- استيل فلورين مع الفورم ألدهيد وأمين ثانوي، مثال: (دي ايتانول أمين، دي ايتيل أمين، N– ميتيل.N– فينيل أمين)بوجود HCl. وهذه المركبات الجديدة هي:

Ia-N,Nبيس(2-هيدروكسي ايتيل) أمينو3)N(2- فلورينيل) بروبانون –3

Ib-N,Nبيس(ايتيل) أمينو، N (3(2- فلورينيل) بروبانون – 3

Ic-(N-ميتيل. - Nفينيل) أمينو،N (3(2 - فلورينيل) بروبانون – 3

تم تحديد بنية المركبات والتعرف عليها باستخدام تحليل أطياف IR و1H-NMR و13C-NMRوLC-MS.

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Published

2016-05-18

How to Cite

1.
Kandil F, Moustapha S, Ahmad T. Synthesis of New Fluorine Derivatives via Mannich Reaction. TUJ-BA [Internet]. 2016May18 [cited 2024Apr.26];37(1). Available from: https://journal.tishreen.edu.sy/index.php/bassnc/article/view/1496

Issue

Vol. 37 No. 1 (2015): العلوم الأساسية

Section

Articles

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