Extracting Lovastatin Compound From The Fungus (Penicillium chrysogenum) And Testing Its Inhibitory Efficacy Against The Fungus (Aspergillus fumigatus

Authors

  • Hajar Nasser Tishreen University
  • Nawal Ali Tishreen University
  • Reem Salamah Tishreen University
  • Amjad Deeb Tishreen University

Abstract

This study was carried out to investigate a possibility of the fungus (Penicillium chrysogenum Thom) to produce lovastatin compound by using solid substrate fermentation method (ssf) in the presence of a mixture of three organic substrates (wheat bran, oat bran, soybeans), carbon and nitrogen sources (potato peels powder, yeast extract, milk powder).

The effectiveness of the obtained lovastatin compound was tested with concentrations of (0.5, 1, 2, 4) mg/ml  in inhibiting the growth of  pathogenic fungus (Aspergillus fumigatus Fresenius).

The analysis of sample of obtained extract by using an infrared spectroscopy device (FTIR) showed presence of several of functional groups belong to lovastatin compound such as (hydroxil, methyl, lactone, and ester).

The average of concentration of lovastatin compound in fermentation experments reached (21.5, 27.1, 41.83, 25.03) mg/g dry substrate in the days (4, 7, 10, 13) respectlively.

The obtained lovastatin compound  showed inhibiting the growth of the  fungus (A.fumigatus) with inhibitory ratios reached (72.12, 73.93, 78.78, 89.09)% at concentrations (0.5, 1, 2, 4) mg/ml respectively.

Author Biographies

Hajar Nasser, Tishreen University

Professor, Department of Chemistry, Faculty of Sciences

Nawal Ali, Tishreen University

Professor , Department of Botany, Faculty of Sciences,

Reem Salamah, Tishreen University

Assistant Professor,  Department of  Pharmacognosy, Faculty of Pharmacy,

Amjad Deeb, Tishreen University

PhD Student, Department of  Environmental Chemistry at Higher Institute for Environmental Researches, Faculty of Sciences

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Published

2021-09-16

How to Cite

1.
ناصر ه, علي ن, سلامة ر, ديب ا. Extracting Lovastatin Compound From The Fungus (Penicillium chrysogenum) And Testing Its Inhibitory Efficacy Against The Fungus (Aspergillus fumigatus. TUJ-BA [Internet]. 2021Sep.16 [cited 2024Nov.24];43(4). Available from: https://journal.tishreen.edu.sy/index.php/bassnc/article/view/10850

Issue

Vol. 43 No. 4 (2021): Tishreen University Journal of Research and Scientific Studies - Basic Sciences Series

Section

Articles

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