Age Related Changes in Central Corneal Thickness and Endothelial Cell Density
Abstract
Purpose: To determine the influence of age on central corneal thickness (CCT), endothelial cell density (ECD), average cell area (MCA), coefficient of variation in cell size (CV), and percentage of regular hexagonal cells (EX).
Methods: Specular microscopy was performed in (421) eyes of 220 healthy Syrian volunteers, they were divided by age into seven groups. Central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation (CV) in cell area, percentage of regular hexagonal cells (EX), average cell area (MCA) were studied.
Results: A total of 113 (51.40%) women and 107 (48.60%) men participated in the study. Average ECD (cell/mm2) ranged from 2925±197.5 in 18-29 years old to 2280±13.1 in
80-87 years old. A strong inverse correlation was observed between age and corneal ECD (r = -0.9, p = 0.0001), CCT (μm) ranged from 566±21.6 in 18-29 years old to 548±6.04 in 80-87 years old. A weak inverse correlation was observed between age and CCT (r= - 0.2). There was also a statistically significant increase in CV and MCA with increasing age. There was also a statistically significant decrease in EX with age. There was no statistically significant difference in studied variables between genders.
Conclusion: Central corneal thickness and endothelial cells density decreases significantly with age. The coefficient of variation and the mean cell size of the elderly increases, in contrast, the number of hexagonal cells decreases.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.